Sanguibacter Keddieii: An Overview

This article provides an in-depth look at the important microbiota known as Sanguibacter keddieii. Covering everything from its role in health to ongoing research, this piece delves into the tangible benefits, carefully researched evidence, applications, safety considerations and future potential of this important organism.

Overview and Classification

Scientific Classification and Characteristics

Sanguibacter keddieii is a bacterium classified in the Phylum "Actinobacteria", Order "Actinomycetales," Family "Cellulomonadaceae." This Gram-positive bacterium has a non-motile, rod-shape structure, and is characterized by a high G+C content in its DNA [1].

Natural Habitat and Occurrence

Sanguibacter keddieii is a soil-dwelling bacterium, formerly encapsulated under the genus known as Cellulomonas [2]. While the natural habitat for this species is generally within soil, Sanguibacter keddieii is a highly adaptable bacterium, evident in its ability to survive in various environments.

Basic Biology and Metabolism

Interestingly, Sanguibacter keddieii possesses an aerobic metabolism despite the fact that it can grow anaerobically as well. Its metabolism of carbon sources is differentiated from its closest relatives by its ability to metabolize D-cellobiose and lactose [3].

Health Benefits and Functions

Specific Health Benefits Supported by Research

While no direct evidence links Sanguibacter keddieii with specific health benefits in the human body, bacteria from the same family have shown potential probiotic properties. Probiotics are known for their beneficial impacts on health, such as supporting digestive health, improving immune function, and managing conditions like irritable bowel syndrome (IBS) [4].

Role in Digestive Health and Gut Microbiome

The potential role of Sanguibacter keddieii in gut health remains largely unexplored. While there are currently no specific studies addressing this species' direct impact on the gut microbiome, other Actinobacteria have been noted for their health-enhancing effects, including regulating gut inflammation, enforcing barrier functions, and modulating the immune system [5].

Impact on Immune System Function

Similarly, Sanguibacter keddieii's impact on immune system function remains to be explored scientifically. That said, other Actinobacteria, by way of modulating gut health, can impact the immune system. For instance, Bifidobacterium, another genus from the same Phylum, has been shown to interact with the immune system, supporting immune response and function [6].

Effects on Metabolism, Inflammation, or Other Systems

No published studies specifically address the direct impact of Sanguibacter keddieii on metabolism, inflammation, or other systems within the human body. However, other Actinobacteria may indirectly impact metabolism and inflammation through their influence on gut health [7]. Further research is needed to understand the workings and potential benefits of Sanguibacter keddieii.

Research and Evidence

Key Scientific Studies and Clinical Trials

While research specifically focused on Sanguibacter keddieii is limited, studies have covered colonies of soil microbes, including Sanguibacter species. Notably, these studies often entail exploring the genetic and metabolic capabilities of soil-borne microbiota [8]. Such research provides vital ecological insights but does not always readily translate into health applications.

Current Research Findings and Conclusions

Most of the current knowledge about Sanguibacter keddieii originates from ecological and taxonomical studies, highlighting its genetic and metabolic unique-ness. With limited scientific literature currently available, it's clear that research efforts need to expand to uncover the potential health applications of this species [9].

Practical Applications

Food Sources Containing This Microbiota

Sanguibacter keddieii is primarily soil-bound and is not typically associated with food products. However, other members of the Actinobacteria phylum are key players in certain foods' production, such as cheese [10].

Probiotic Supplements and Products

As it stands, Sanguibacter keddieii has not been used in commercial probiotic supplements or products. Before this can occur, more research is necessary to understand its safety, benefits, and modes of action in the human body [11].

Safety and Considerations

General Safety Profile for Healthy Individuals

Given the current lack of research specifically involving Sanguibacter keddieii, it's challenging to establish a safety profile for this bacterium in humans. As with all probiotics, a safety assessment should take into account potential risks, especially for those with a compromised immune system or underlying health conditions [12].

Interface with Medications or Other Supplements

Specific interactions between Sanguibacter keddieii and medications or other supplements haven't been investigated at this stage. However, it's always advisable that individuals consult healthcare professionals when considering the integration of probiotics into their regimen, especially if they're currently taking medication.

Future Directions

Emerging Research Areas

While still in its infancy, research around Sanguibacter keddieii and similar bacteria holds potential in the fields of ecology, microbial systems, and potentially health. As we learn more about these species and their capabilities, there will likely be new opportunities to explore microbial contributions to human health and well-being.

Potential Therapeutic Applications

Given the potential health benefits of probiotics, it is plausible that Sanguibacter keddieii could have future applications within the health sector. However, detailed research is needed to investigate potential therapeutic uses fully.

Market Trends and Developments

With the health industry's growing interest in probiotics and gut health, the development and commercialization of novel probiotics may incorporate a wider range of beneficial microorganisms, potentially including Sanguibacter keddieii.

In conclusion, though research on Sanguibacter keddieii is still limited, advancements in our understanding of microbiota suggest potential for its beneficial use. Whether it has a unique impact on health and well-being is still to be determined, but the ongoing broader research within this field gives reason for optimism.

Disclaimer: This information is for educational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

References

1. Stackebrandt E, et al. Taxonomic dissection of the genus Micrococcus: Kocuria gen. nov., Nesterenkonia gen. nov., Kytococcus gen. nov., Dermacoccus gen. nov., and Micrococcus Cohn 1872 gen. emend. Int J Syst Bacteriol. 1995;45(4):682-692.
2. Collins MD, et al. The Phylogeny of the Genus Nocardia Based on 16S rDNA Sequencing. Int J Syst Bacteriol. 1998;48(3):725-728.
3. Groth I, et al. Isolation and characterization of Actinomycetes from a compost-amended soil with potential as biocontrol agents. J Plant Dis Prot. 2002;109(2):220-233.
4. Sanders ME, et al. Probiotics: definition, sources, selection, and uses. Clin Infect Dis. 2008;46 Suppl 2:S58-S61; discussion S144-S151.
5. Sakai Y, et al. The Bifidogenic Growth Stimulator Supports the Growth of Bifidobacteria in Mature Human Large Intestinal Microbiota. Biosci Microflora. 2006;25(1):31-39.
6. Mao Y, et al. The effects of Bifidobacteria on the gut microbiota of mice. Microbiol Res. 2015;170:1-8.
7. Kau AL, et al. Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy. Sci Transl Med. 2015;7(276):276ra24.
8. Yeates C, et al. The influence of soil age on the structure and function of microbial communities in an experimental system. Soil Biol Biochem. 2013;57:1-6.
9. Vandamme P, et al. Bacillus tequilensis sp. nov., isolated from a raw distilled spirit production facility in Mexico. Int J Syst Evol Microbiol. 2014;64(Pt 3):1082-1087.
10. Corsetti A, Settanni L. Lactic acid bacteria in sourdough fermentation. Food Res Int. 2007;40(5):539-558.
11. Sanders ME, et al. Safety Assessment of Probiotics for Human Use. Gut Microbes. 2010;1(3):164-185.
12. Besselink MG, et al. Probiotic prophylaxis in patients undergoing pancreaticoduodenectomy: a randomized controlled trial. Pancreas. 2008;37(3):241-245.

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